The 2021–22 Conference USA men's basketball season began with practices in October 2021, followed by the start of the 2021–22 NCAA Division I men's basketball season in November.

Conference play starts in late December 2021 and will end in March 2022, after which all 14 member teams will participate in the 2022 Conference USA tournament at The Ford Center at The Star in Frisco, Texas.

[1] UAB was picked as a narrow favorite to finish first in Conference USA by a poll of the league's 14 head coaches.

[2] () first place votes Rodney Terry resigned as head coach of UTEP after three seasons to accept an assistant coaching position at Texas.

[3]Joe Golding was then hired as the new head coach of the Miners.