A total of eleven clubs qualified from the overseas leagues, two each from Guadeloupe, French Guiana, Martinique, Réunion, and one each from Mayotte, New Caledonia and Tahiti.
[3] In 2020–21 Club Franciscain from Martinique survived longest in the competition, beating a number of overseas clubs in playoff rounds to reach the round of 32, equalling the record for an overseas team's progression in the competition.
[18] Note: French Guiana League structure (no promotion to French League structure):Régional 1 (R1)Régional 2 (R2) Due to the continuing COVID-19 pandemic in Martinique, football in the territory was still suspended in mid-October.
The winner, A.S. Saint Pierraise, gained entry to the third round draw of the Pays de la Loire region.
[28] A total of eleven teams qualified from the Pays de la Loire preliminary rounds.
[3] In 2020–21, Voltigeurs de Châteaubriant and Olympique Saumur FC progressed furthest in the main competition, reaching the round of 16 before losing to Montpellier and Toulouse respectively.
22 clubs from Régional 1 and 12 from Championnat National 3 entered at the third round stage, along with the qualifier from Saint Pierre and Miguelon.
[3] In 2020–21, SO Romorantin progressed furthest in the main competition, reaching the round of 32 before losing to Voltigeurs de Châteaubriant.
[3] In 2020–21, Gazélec Ajaccio progressed furthest in the main competition, reaching the round of 32 before losing to Lille.
[3] In 2020–21, UF Mâconnais progressed furthest in the main competition, reaching the round of 64 before losing to FC Saint-Louis Neuweg.
[3] In 2020–21, CS Sedan Ardennes progressed furthest in the main competition, reaching the round of 16 before losing to Angers.
820 teams entered at the first round stage, with clubs from all district level leagues and Régionale 3 included.
Additionally, seven Régionale 2 teams, drawn at random, were included at this stage to take account of the late promotion of Sedan.
[3] In 2020–21, Aubagne FC progressed furthest in the main competition, reaching the round of 32 before losing to Toulouse.
[3] In 2020–21, Canet Roussillon FC progressed furthest in the competition, reaching the quarter-finals, beating Marseille along the way, before losing to Montpellier.
[80] The third round draw, which saw the entry of the Championnat National 3 teams from the region, was published on 17 September 2021.
[81] The fourth round draw, which saw the entry of the Championnat National 2 teams, was published on 23 September 2021.
[82] The fifth round draw, which saw the entry of the single Championnat National tean in the region, was made on 6 October 2021.
[3] In 2020–21, US Boulogne progressed furthest in the main competition, reaching the round of 16 before losing to Canet Roussillon FC.
[88] On 21 July 2021, the Oise district league published that 1024 teams from the region had entered the competition.
[3] In 2020–21, US Quevilly-Rouen progressed furthest in the main competition, reaching the round of 64 before losing to Red Star.
[3] In 2020–21, US Montagnarde progressed furthest in the main competition, reaching the round of 32 before losing to Olympique Saumur FC.
[113] The third round draw was published on 9 September 2021, with the teams from Championnat National 3 entering at this stage.
[114] The fourth round draw was published on 23 September 2021, with the teams from Championnat National 2 entering at this stage.
[3] In 2020–21, Red Star progressed furthest in the main competition, reaching the round of 16 before narrowly losing against Lyon on penalties.
[3] In 2020–21, GFA Rumilly-Vallières progress furthest in the main competition, becoming the first fourth tier side to reach the semi-final by beating Toulouse in the quarter-finals, before losing to Monaco.
[124] The draw for the first round, featuring 836 teams from the district leagues and Régional 3, was made on 2 August 2021.
[126] The third round draw took place on 8 September 2021, and saw the Régional 1 and Championnat National 3 teams entering.
[127] The fourth round draw took place on 22 September 2021, and saw the Championnat National 2 teams entering.
[128] The fifth round draw, which saw the Championnat National teams entering, was made on 6 October 2021.