Crewe's relegation to League Two was confirmed following a 2–0 defeat at Doncaster on 9 April 2022.

[1] Crewe Alexandra announced they would play friendlies against Nantwich Town,[2] Witton Albion,[2] Ashton United,[2] Wolverhampton Wanderers,[2] Stoke City,[2] Kidsgrove Athletic,[2] Nottingham Forest,[3] Oldham Athletic,[2] Wolverhampton Wanderers U23s[3] and Huddersfield Town[4] as part of their pre-season preparations.

Source: [citation needed] Crewe's fixtures were announced on 24 June 2021.

[7] Crewe were drawn at home to Swindon Town in the first round.

Crewe were drawn at home against Sandbach United in the first round.