It was sponsored by the betting company SuperSport and known as the SuperSport Hrvatski nogometni kup for sponsorship purposes.
[1] The defending champions were Dinamo Zagreb, having won their 16th title the previous year by defeating Istra 1961 in the final.
The following 48 teams qualified for the competition: The draw for the preliminary single-legged round was held on 3 August 2021 and the matches were scheduled on 25 August 2021.
The draw for the preliminary single-legged round was held on 26 August 2021 and the matches were scheduled on 22 September 2021.
16 and so on, with bigger numbers hosting a tie.