The 2021–22 Cupa României was the 84th season of the annual Romanian primary football knockout tournament.

The winner qualified for the second qualifying round of the 2022–23 UEFA Europa Conference League.

Times up to 30 October 2021 and from 26 March 2022 are EEST (UTC+3).

Times between 31 October 2021 and 27 March 2022 are EET (UTC+2).

The matches were played on 30 November, 1 and 2 December 2021.