The 2021–22 Cupa României was the 19th season of the annual Romanian primary football knockout tournament.

[1] The 16 qualified teams played the 8 matches on April 16 and 27.

[1] The 8 qualified teams played the 4 matches on May 11.

[1] The 4 qualified teams played the two matches on May 25.

[1] The final was played on June 5 on the Arcul de Triumf stadium.