Teams played each other twice on a home and away basis, before the league split into two groups after phase 1 matches were completed.
Due to Wales losing a European place, the format of the play-offs changed, with the prize now being a place in the Scottish Challenge Cup.
Due to the COVID-19 pandemic, the Cymru North and Cymru South leagues were unable to be played the previous season, therefore no teams were able to be promoted.
(H) – Home team(A) – Away team The winner for each respective division's FAW Fair Play Table was to be given £1,000 prize money and the FAW Fair Play Trophy.
The winners of the Nationwide Building Society Fair Play Award for the 2021-2022 Cymru Premier season are Connah's Quay Nomads[11]