[4][5] The 2021–22 season began on 24 July, thirteen days after the UEFA Euro 2020 final.
It was also an interruption of Slavia Prague's record unbeaten streak of 54 matches in the first league.
However, Slovácko did not confirm the point tally in the following matches and finished fourth during winter break.
On 8 May 2021 Hradec Králové defeated Dukla Prague 2–1 and secured the promotion with three matches remaining.
On 8 May 2021, Opava became the first team to be relegated to FNL after a 1–1 draw at Zlín with three games remaining, ending their three-year stay in the top flight.
[8] On 16 May 2021, Zbrojovka became the second team to be relegated to FNL after a 1–1 draw at Slovan Liberec with two games remaining, ending their one-year stay in the top flight.
[9] On 23 May 2021, Příbram's relegation was confirmed following a 0–1 defeat at home against Pardubice with one game remaining, ending their First League tenure after three years.