The relegated teams were replaced by 2020–21 1st Division champions Viborg FF, who returned after four years of absence, as well as the runners-up Silkeborg IF who returned after a one-year absence.
Note: Flags indicate national team as has been defined under FIFA eligibility rules.
Points and goals carried over in full from the regular season.
Points and goals carried over in full from the regular season.
The winners earned a place in the Europa Conference League second qualifying round.