The 2021–22 DePaul Blue Demons women's basketball team represented DePaul University during the 2021–22 NCAA Division I women's basketball season.

The Blue Demons were led by thirty-sixth year head coach Doug Bruno and played their home games at the Wintrust Arena as members of the Big East Conference.

[1][2] As the fourth seed in the Big East tournament they lost in the Quarterfinals to Villanova.

They received an at-large invitation to the WNIT, where they played in the Rockford Regional.

Roster Last update: January 30, 2022 Source:[3]