The 2021–22 season is Debreceni VSC's 42nd competitive and consecutive season in the Nemzeti Bajnokság I and 73rd year in existence as a handball club.

Since August 2018 they are sponsored by Schaeffler Group, so the official name for the team is DVSC Schaeffler.

Includes all competitive matches.

The list is sorted by shirt number when total goals are equal.

List of the home matches: