The Fightin' Blue Hens, led by fifth year head coach Natasha Adair, played their home games at the Bob Carpenter Center and were members of the Colonial Athletic Association (CAA).

As the second seed in the CAA tournament the defeated William & Mary in the Quarterfinals, Towson in the Semifinals, and Drexel in the Final to win their third championship in team history.

The team was given an automatic qualifier to the 2021 Women's National Invitation Tournament where they won the Charlotte Regional Championship by defeating Villanova.

[1][2] The team lost to eventual WNIT Champion Rice in the semifinals, marking Delaware's furthest advance in the tournament.

[3] The team received Top 25 votes in the Coaches Poll of the 2020–21 NCAA Division I women's basketball rankings in weeks 8, 9, 16, and 17.