The 2021–22 Delaware State Hornets men's basketball team represented Delaware State University in the 2021–22 NCAA Division I men's basketball season.

The Hornets, led by first-year head coach Stan Waterman, played their home games at Memorial Hall in Dover, Delaware as members of the Mid-Eastern Athletic Conference.

In a season limited due to the ongoing COVID-19 pandemic, the Hornets finished the 2020–21 season 3–16, 1–11 in MEAC play to finish in fourth place in the Northern division.

[1] On April 1, 2021, the school fired head coach Eric Skeeters after three seasons at Delaware State.

[2] On June 3, the school named high school coach Stan Waterman the team's new head coach.