The 2021–22 Denver Pioneers men's basketball team represented the University of Denver in the 2021–22 NCAA Division I men's basketball season.

The Pioneers, led by first-year head coach Jeff Wulbrun, played their home games at Hamilton Gymnasium in Denver, Colorado, as members of the Summit League.

In a season limited due to the ongoing COVID-19 pandemic, the Pioneers finished the 2020–21 season 2–19, 1–13 in Summit League play to finish in last place.

They failed to qualify for the Summit League tournament.

[1] On March 1, 2021, the school announced that there would be a "change in leadership," ending Rodney Billups' five-year tenure with the team.