The 2021–22 Derde Divisie season was the sixth edition of the Dutch fourth tier, formerly called Topklasse, since the restructuring of the league system in the summer of 2016.
Since Kozakken Boys and GVVV finished 16th and 17th respectively, they will have to play relegation playoffs against teams from the Derde Divisie for one spot in the 2022–23 Tweede Divisie.
[7] Since ODIN '59 and VVOG finished 16th and 17th respectively, they will have to play relegation playoffs against teams from the Hoofdklasse Saturday for two spots in the 2022–23 Derde Divisie.
Since Hoogland and EVV finished 16th and 17th respectively, they will have to play relegation playoffs against teams from the Hoofdklasse Sunday for two spots in the 2022–23 Derde Divisie.