The 2021–22 Detroit Mercy Titans men's basketball team represented the University of Detroit Mercy in the 2021–22 NCAA Division I men's basketball season.

The Titans, led by fourth-year head coach Mike Davis, played their home games at Calihan Hall in Detroit, Michigan as members of the Horizon League.

They defeated Green Bay in the first round of the Horizon League Tournament before losing to Northern Kentucky in the quarterfinals.

In a season limited due to the ongoing COVID-19 pandemic, the Titans finished the 2020–21 season 12–10, 10–6 in Horizon League play to finish in third place.

They defeated Robert Morris in the first round of the Horizon League tournament,[2] before falling to Northern Kentucky in the quarterfinals.