The season covers the period from 1 July 2021 to 30 June 2022.

Rovers revealed they would have friendly matches against Rossington Main,[3] Spennymoor Town,[3] Bradford City,[3] Wakefield,[4] Newcastle United,[4] Sheffield United[5] and Harrogate Town[4] as part of their pre-season preparations.

Source: [citation needed] Doncaster's fixtures were announced on 24 June 2021.

[14][15] Rovers were drawn into Northern Group E alongside Manchester City U21s, Rotherham United and Scunthorpe United.

[16] On July 8, the dates for the group matches were confirmed.