The 2021–22 Duquesne Dukes men's basketball team represented Duquesne University during the 2021–22 NCAA Division I men's basketball season.

The team were led by fifth-year head coach Keith Dambrot, and played their home games at the UPMC Cooper Fieldhouse in Pittsburgh, Pennsylvania as a member of the Atlantic 10 Conference.

In a season limited due to the ongoing COVID-19 pandemic, the Dukes finished the 2020–21 season 9–9, 7–7 in A-10 play to finish in ninth place.

In the A-10 tournament they defeated to Richmond in the second round before losing to St. Bonaventure in the quarterfinals.

Sources: Roster Source[1]