[1] A total of 32 teams were involved in the first qualifying round.

[2] The draw was held in EHF office in Vienna.

The pairings for the last 16 and the quarterfinals are based on group stage standings, according to the following bracket.

[10] The 2021–22 EHF European League Finals was played on 28 and 29 May 2022 in Lisbon, Portugal and comprise one leg semifinals, final and a third place game.

[11] The pairings for the semifinals were decided by drawing of lots.