The 2021–22 East Tennessee State Buccaneers men's basketball team represented East Tennessee State University (ETSU) in the 2021–22 NCAA Division I men's basketball season.

The Buccaneers, led by first-year head coach Desmond Oliver, played their home games at the Freedom Hall Civic Center in Johnson City, Tennessee, as members of the Southern Conference (SoCon).

In a season limited due to the ongoing COVID-19 pandemic, the Buccaneers finished the 2020–21 season 13–12 overall, 8–7 in SoCon play, to finish in fifth place.

In the SoCon tournament, they defeated Chattanooga in the quarterfinals,[1] before losing to UNC Greensboro in the semifinals.

[2] On March 30, 2021, Jason Shay resigned after one season as head coach following his support of his players kneeling during the national anthem as protest of social injustice.