The 2021–22 East of Scotland Football League (known as the Central Taxis East of Scotland League for sponsorship reasons) was the 93rd season of the East of Scotland Football League, and the 8th season as the sixth tier of the Scottish football pyramid system.
Transferred from East Premiership South Withdrawn The Premier Division remained with the same 18 clubs as before, after the 2020–21 season was declared null and void.
The league title went down to the final round of matches with Tranent Juniors ultimately winning the league on goal difference ahead of Penicuik Athletic.
All grounds equipped with floodlights, except Humbug Park (Crossgates Primrose).
SFA Club with an SFA Licence[66] eligible to participate in the Lowland League promotion play-off should they win the Premier Division.