The defending champions were Zamalek; they were eliminated in the semifinals by Al Ittihad Alexandria.
El Shams Geziret El Ward Sixteen teams competed in this season – the top fourteen of the previous season and two teams that were promoted from the Egyptian Second Division.
Heliopolis and Al Shams joined as promoted teams.
Al Zohour and Geziret El-Ward were relegated from the 2020-21 season.
All games were hosted at the Hassan Moustafa Sports Hall.