The season started on 25 October 2021 and is concluded on 30 August 2022.
[1] Zamalek are the defending champions, having won their 13th league title in the previous season.
A total of 12 stadiums in 5 governorates were selected by clubs to host their 2021–22 home fixtures.
For example, fixtures between Al Ahly and Ismaily are played in Alexandria.
All matches involving Al Masry are also played in the same city.