The 2021–22 Eredivisie Vrouwen was the twelfth season of the Netherlands women's professional football league.

Defending champions Twente[1] won the league title for the third time in a row.

[2] Twente's Fenna Kalma, the top goal scorer for the season, was named the Women's Eredivisie Player of the Year.

[4] The league changed its format, dropped the split-season scheduling used for several years.

[7] The top two teams qualified for the UEFA Women's Champions League.