The 2021–22 season was Ergotelis' 92nd season in existence and 15th overall in the second tier of the Greek football league system, and 3rd after the foundation of the Super League 2.

The contents of this article cover club activities from 1 June 2021 until 30 May 2022.

Players and Managers may hold more than one non-FIFA nationality.

Source: Competitive matches Win Draw Loss Postponed Win Draw Loss Win Draw Loss Appearances denote players in the starting lineup, with the numbers in parentheses denoting appearances as substitute.

Player has departed in mid-season Last updated: 26 September 2021 Source: Competitive matches Last updated: 6 October 2021 Source: Competitive matches Ordered by ,   and = Number of bookings;   = Number of sending offs after a second yellow card; = Number of sending offs by a direct red card.