The 2021–22 EuroLeague Women was the 64th edition of the European women's club basketball championship organized by FIBA, and the 26th edition since being rebranded as the EuroLeague Women.

In February 2022, the Russian teams (UMMC Ekaterinburg, Dynamo Kursk, and MBA Moscow) were expelled from the tournament by FIBA for the Euroleague Women playoffs, and suspended, due to Russia's invasion of Ukraine.

[3] A total of 20 teams from 10 countries will participate in the 2021–22 EuroLeague Women.

[4] League positions of the previous season shown in parentheses (TH: EuroLeague Women title holders; EC: EuroCup Women title holders).

The draw was held on 19 August 2021 in Freising, Germany.