The 2021–22 Evansville Purple Aces men's basketball team represented the University of Evansville in the 2021–22 NCAA Division I men's basketball season.

The Purple Aces were led by head coach Todd Lickliter in his second full season at Evansville and played their home games at the Ford Center in Evansville, Indiana as members of the Missouri Valley Conference (MVC).

They lost to Valparaiso in the first round of the MVC tournament.

In a season limited due to the ongoing COVID-19 pandemic, the Purple Aces finished the 2020–21 season 9–16, 7–11 in MVC play, to finish in a three-way tie for fifth place.

5 seed in the MVC tournament, they lost to Indiana State in the quarterfinals.