(women) season was the club's fifth consecutive campaign in the FA Women's Super League, the highest level of the football pyramid.

After a poor start to the season, Everton sacked manager Willie Kirk on 16 October 2021.

[1] Jean-Luc Vasseur, who had last been in charge of Olympique Lyon until his sacking in April 2021, was announced as his replacement on 29 October.

[3] Chris Roberts and Claire Ditchburn were named as interim managers.

[4] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.