Crotone's first season back in second division of the Italian football league, the Serie B, and the 112th as a football club.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Source: Serie B The league fixtures were announced on 24 July 2021.