[1][2] Coach Diego Vásquez renewed his contract for one year and lead the team for his 16th consecutive tournament.

[3][4] Due to poor results in both domestic and international fronts, he was sacked during the Clausura tournament.

He broke a league record of 350 consecutive games as manager.

He was temporarily recplaced by interim coach and former star César Obando and subsequently by Argentinian manager Hernán Medina, who managed to win the Clausura title.

This is a list of players that were playing for Motagua during the 2021–22 season and were called to represent Honduras at different international competitions.