2021–22 FA WSL

[2] It was the fourth season after the rebranding of the four highest levels in English women's football.

Members of the WSL since it was founded in 2011, it ended Birmingham's twenty-year stint as a top-flight club having last been promoted as the 2001–02 FA Women's Premier League Northern Division champions.

[5] Two teams changed home ground prior to the start of the season: Birmingham City relocated from Damson Park to St Andrew's, home of the team's male affiliate since 1906.

[6] Leicester City prepared for their maiden WSL season by moving to their parent club's main stadium, King Power Stadium, with Burton Albion's Pirelli Stadium serving as backup when fixtures clash with Leicester's men's side.

In order to preserve chronological progress, any postponed matches are not included in the round at which they were originally scheduled, but added to the full round they were played immediately afterwards.