In a change from previous years, teams competing in the UEFA Women's Champions League group stage were exempt from the League Cup group stage, earning a provisional bye to the quarter-finals.
Because Manchester City entered the group stage of the League Cup following their elimination from the second qualifying round of the Champions League, the best-placed runner-up also progressed with the five group winners.
With only two teams now receiving byes to the League Cup quarter-finals, the best-placed runner-up will also progress with the five group winners to make up the final eight.
Arsenal also entered at this stage having progressed from the Champions League qualifying rounds.
On 20 December 2021, it was announced the 2022 FA Women's League Cup Final would be held at Plough Lane, the home of AFC Wimbledon, for the first time.