The 2021–22 Dynamo Moscow season was the club's 99th season and fifth season back in the Russian Premier League, following their promotion in 2016–17.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.