In addition to the domestic league, FC Groningen participated in this season's edition of the KNVB Cup.

FC Groningen finished 2021–22 Eredivisie season as 12th.

Jørgen Strand Larsen (31E-3K), Neraysho Kasanwirjo (31E-3K), Peter Leeuwenburgh (33E-1K) and Romano Postema (31E-3K) were the most appeared players in this season with 34 appearances.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Fixtures Source: Soccerway Source: ESPN The league fixtures were announced on 11 June 2021.