In addition to the domestic league, Schalke 04 participated in this season's edition of the domestic cup, the DFB-Pokal.

This was the 21st season for Schalke in the Veltins-Arena, located in Gelsenkirchen, North Rhine-Westphalia.

The season covered a period from 1 July 2021 to 30 June 2022.

Note: Players' appearances and goals only in their Schalke career.

Win Draw Loss Last updated: 16 May 2022 Source: Soccerway Source: Soccerway The league fixtures were announced on 25 June 2021.