The 2021–22 season is the 64th season in the existence of FC Slovan Liberec and the club's 29th consecutive season in the top flight of Czech football.

In addition to the domestic league, Slovan Liberec will participate in this season's edition of the Czech Cup.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Win Draw Loss Fixtures Last updated: 13 March 2022 Source: Soccerway