In addition to the domestic league, Spartak Moscow participate in this season's editions of the Russian Cup and the UEFA Champions League.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Source: FBref The draw for the third qualifying round was held on 19 July 2021.

[59] RB Leipzig won on walkover after Spartak Moscow were disqualified as a result of UEFA's suspension of Russian clubs from all competitions following the Russian invasion of Ukraine.