The 2021–22 season was the 64th season in the existence of FC Ufa and the club's 19th & final consecutive season in the top flight of Russian football.

In addition to the domestic league, FC Ufa were participated in this season's editions of the Russian Cup.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Win Draw Loss Fixtures Last updated: 28 May 2022 Source: Soccerway Last updated: 21 May 2022.