The 2021–22 First Women's Basketball League of Serbia (Serbian Cyrillic: Прва женска лига Србије 2021–22.)
Also, it will be the 78th national championship played by Serbian clubs inclusive of the nation's previous incarnations as Yugoslavia, Serbia and Montenegro.
[citation needed] Crvena zvezda mts is the defending champion.
A total of 12 teams participated in the 2021–22 First Women's Basketball League of Serbia as confirmed by the Basketball Federation of Serbia on 30 June 2021.
The four highest-placed teams from the Regular season will qualify for the Playoffs.