The Panthers began the season 3–0–0 for the second time in team history in as many years.
[3] Quenneville resigned from his coaching duties as a result of the fallout from the 2010 Chicago Blackhawks sexual assault scandal on October 28, 2021.
[7] The Panthers became the first team to clinch a berth in the 2022 Stanley Cup playoffs following a 5–3 win over the Buffalo Sabres on April 3, 2022.
Notes: Below are the Florida Panthers' selections at the 2021 NHL Entry Draft, which were held on July 23 to 24, 2021.
It was held virtually via Video conference call from the NHL Network studio in Secaucus, New Jersey.