Ampem Darkoa Ladies were crowned champions after beating Hasaacas Ladies 5–3 on penalty after 1–1 draw after extra time during the Championship final.
[1] In 2021, the Executive Council of the Ghana Football Association (GFA) decided to expand the League from its current format 16 Clubs to 18 Clubs beginning from this season, meaning nine teams for the respective zones to allow for a minimum of 16 league matches in a season.
Winners of the northern and southern zones then meet in a championship final to declare the champions for the season.
[4] Note: Table lists in alphabetical order.
Note: Table lists in alphabetical order.