[1][2] Accra Hearts of Oak are the defending Champions.
In June 2021, MTN renewed their sponsorship for the competition for three extra years with 4 million Ghana cedis with focus on the 2022 Ghanaian FA Cup.
[4] Star times also is set to contribute $200,000 as part of their full $1,000,000.00 for the entire 2021–22 football season for the second year of the sponsorship deal with the Ghana Football Association.
[5] The draw for the preliminary round was made on 25 November 2021.
Only second tier and third tier teams joined the round, as the Premier League teams received a bye from the round.