Lincoln Red Imps were the reigning champions, winning the title on the final day of the 2020–21 season.

The structure of the league was expected to follow that of the previous two seasons.

The winners of the Challenge Group received the GFA Challenge Trophy and a bye to the second round of the next season's Rock Cup.

Boca Gibraltar were expelled from the league in December 2020 and did not return.

Note: Flags indicate national team as has been defined under FIFA eligibility rules.