In addition to the I-League, Gokulam Kerala also participated in the Durand Cup, IFA Shield, and continental tournament AFC Cup.

I-league fixtures were published on 9 December 2021.

[36] After the commencement of the first match-week of the league on 27 December 2021, the tournament got suspended on 29 December due to reports of numerous COVID-19 cases among the players and staff.

[37] All India Football Federation released new dates on 1 February 2022, with a revised schedule of the league resuming from 3 March.

Gokulam Kerala FC will play in the AFC Cup Group Stage 2022 by virtue of a special dispensation awarded by the Asian Football Confederation (AFC).