[6] Each tie in the knockout phase, apart from the quarter-finals and the semi-finals, was played by a single match.

If the score was level at the end of normal time, extra time was played, followed by a penalty shoot-out if the score was still level.

The team that scored more goals on aggregate over the two legs advanced to the next round.

If no goals were scored during extra time, the winners were decided by a penalty shoot-out.

In the round of 16, if the score was level at the end of normal time the two-legged rule was applied.The mechanism of the draws for each round is as follows: The draw took place on 18 November 2021.

[8] Former Greek international and member of the UEFA Euro 2004 squad, Kostas Katsouranis, made the draw using a manually operated lottery ball cage.