A total of fourteen teams contested this season's league, which began on 10 September 2021 and concluded on 12 June 2022.
This was because the previous season 2020-21, Aarhus Håndbold had gone bankrupt and was forced to leave the league.
[4] The team TMS Ringsted finished last in the regular season, and should therefore under normal circumstances have been relegated.
They decided however to appeal the relegation, and it was found that due to Aarhus Håndbold's bankruptcy, they had the right to remain in the league.
[6] The following 15 clubs competed in the Håndboldligaen during the 2021–22 season: Semifinals were played best-of-three format.