The 2021–22 season was Hamilton Academical's first season back in the second tier of Scottish football, following their relegation from the Scottish Premiership at the end of the 2020–21 season.

Hamilton began the season under the management of Brian Rice who had been at the club since January 2019.

Rice would resign from his position after only the second game of the league season following a 1–0 loss to Greenock Morton.

[1] Former Hamilton player and assistant manager Stuart Taylor returned to the club after being appointed as their new head coach on 20 August.

[2] Win Draw Loss Postponed As of 29 April 2022[3]