The 2021–22 Hampton Pirates men's basketball team represented Hampton University in the 2021–22 NCAA Division I men's basketball season.

The Pirates, led by 13th-year head coach Edward Joyner Jr., played their home games at the Hampton Convocation Center in Hampton, Virginia as members of the Big South Conference.

10 seed in the Big South tournament, they lost to High Point in the first round.

In a season limited due to the ongoing COVID-19 pandemic, the Pirates finished the 2020–21 season 11–14, 9–9 in Big South play, to finish in seventh place.

They lost to Radford in the quarterfinals of the Big South tournament.