Borac emerged as the men's champion, while Grude claimed the women's title.
Sixteen teams joined the regular season, played as double round robin tournament.
[1] The following 16 clubs compete in the Handball Premier League during the 2021–22 season.
[2] Twelve teams joined the regular season, played as double round robin tournament.
[3] The following 12 clubs compete in the Handball Premier League during the 2021–22 season.