Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

[53] Hartlepool United were drawn at home to Crewe Alexandra in the first round.

[54][55] Hartlepool were drawn into Northern Group A alongside Carlisle United, Everton U21s and Morecambe.

[56] In the knock-out stages, United were drawn at home to Bolton Wanderers in the third round.

On 1 May 2022, Hartlepool's end of season awards were held at the Hardwick Hall Hotel in Sedgefield.